DNA vaccination: an immunological perspective
نویسندگان
چکیده
La vacunación con DNA es una nueva y prometedora estrategia para la prevención y el tratamiento de muchas enfermedades debido a su habilidad para inducir una respuesta inmunitaria tanto humoral como celular, frente al antígeno codificado por el DNA recombinante. Una vez inoculado en el huésped, el DNA se introduce en las células, donde el antígeno se expresa y se procesa para ser después reconocido por el sistema inmunitario como si se tratase de una infección natural. Esta tecnología presenta grandes esperanzas para ser usada en la inmunoterapia del cáncer y se espera que llegue a ser el método preferido para la próxima generación de vacunas, particularmente adecuadas contra infecciones intracelulares para las que no hay vacunas efectivas. Esta revisión se centra en los mecanismos por los cuales la vacunación con DNA es capaz de inducir una respuesta inmunitaria y los abordajes que se están llevando a cabo para su optimización. También se ofrece una visión general sobre las aplicaciones de la vacunación con DNA.
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